Department of Chemistry & Biochemistry
University of the Sciences in Philadelphia
Julian Snow, Ph. D.
Professor of Chemistry
How to reach me
Principal areas of research:
1. We are using differential scanning calorimetry (DSC)
and isothermal titration calorimetry (ITC) to investigate the structural
properties of the exchangeable apolipoproteins apo A and the three common
isoforms of apo E, and to conduct a thermodynamic characterization of the
interaction of these proteins with phospholipid.
2. We are investigating the binding of amphiphiles to synthetic phospholipid vesicles using ITC and other physical techniques. We are determining the effects of curvature of the bilayer on the thermodynamic parameters that characterize the binding. Our results, as well as the results of others, have suggested that binding of amphiphiles increases bilayer fluidity for larger vesicles. We are interested in verifying this, and, if so, are membrane-related functions such as simple diffusion affected?
Chemistry 348(Biochemistry and Molecular Biology II)
Chemistry 343(Principles of Biochemistry III - Intermediary Metabolism)
Chemistry 321(Physical Chemistry I - Thermodynamics)
Chemistry 341(Principles of Biochemistry I - Biomolecular Structure)